Symbol
Name
ID

Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
MGI:104741

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA level	Increased circulating IgG level	Polyclonal elevation of IgM	Decreased circulating antibody level	Paraproteinemia	Anemia	Impaired lymphocyte transformation with phytohemagglutinin	Hodgkin lymphoma	Multiple myeloma	Splenomegaly
Disease(s) Associated with NFKBIA	Increased circulating IgA level	Increased circulating IgG level	Polyclonal elevation of IgM	Decreased circulating antibody level	Paraproteinemia	Anemia	Impaired lymphocyte transformation with phytohemagglutinin	Hodgkin lymphoma	Multiple myeloma	Splenomegaly
ectodermal dysplasia and immunodeficiency 2
Hodgkin's lymphoma
multiple myeloma

Mouse Phenotypes

hematopoietic system phenotype

increased activation-induced B cell apoptosis

increased T cell apoptosis

abnormal granulocyte differentiation

decreased B cell proliferation

increased B cell proliferation

decreased T cell proliferation

increased T cell proliferation

thymus atrophy

decreased thymocyte number

increased thymocyte number

abnormal erythropoiesis

abnormal B cell differentiation

decreased transitional stage T2 B cell number

increased immature B cell number

increased pro-B cell number

decreased double-negative T cell number

decreased double-positive T cell number

increased double-positive T cell number

abnormal myelopoiesis

extramedullary hematopoiesis

anemia

increased bone marrow cell number

abnormal granulocyte morphology

increased granulocyte number

decreased mature B cell number

decreased B-2 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

decreased B cell number

increased pre-B cell number

abnormal T cell number

decreased CD4-positive, alpha-beta memory T cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased memory T cell number

decreased regulatory T cell number

increased activated T cell number

increased single-positive T cell number

increased macrophage cell number

increased monocyte cell number

increased leukocyte cell number

abnormal marginal zone B cell morphology

small spleen

spleen atrophy

absent spleen germinal center

decreased IgA level

increased IgA level

increased IgE level

decreased IgG1 level

decreased IgG2b level

increased IgG level

abnormal T cell activation

abnormal macrophage physiology

Availability

Mouse Genotype

Nfkbia^tm1.1Kbp/Nfkbia^tm1.1Kbp

Nfkbia^tm1.1Pjc/Nfkbia^tm1.1Pjc

Nfkbia^tm1.1Smiy/Nfkbia^tm1.1Smiy

Nfkbia^tm1Bal/Nfkbia^tm1Bal

Nfkbia^tm1Fey/Nfkbia^tm1Fey

Nfkbia^tm1Stw/Nfkbia^tm1Stw

Nfkbia^tm1.1Smiy/Nfkbia⁺

Nfkbia^tm1Kbp/Nfkbia^tm1Kbp
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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